Tubulin inhibitor 35

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Tubulin inhibitor 35 (compound 6b) 是拓扑异构酶 I (IC50=~50 μM) 和微管蛋白聚合 (IC50=5.69 μM) 的双重抑制剂。Tubulin inhibitor 35 抑制 MGC-803 和 RKO 细胞株的迁移和侵袭，并通过在 G2/M 期阻滞细胞周期诱导凋亡 (apoptosis)。Tubulin inhibitor 35 对胃肠道肿瘤有较强的抑制作用 (对 MGC-803 的 IC50=0.09 μM，对 RKO 的 IC50=0.2 μM)。

Tubulin inhibitor 35 (compound 6b) is a dual inhibitor of topoisomerase I (IC50=~50 μM) and tubulin polymerization (IC50=5.69 μM). Tubulin inhibitor 35 inhibits migration and invasion of MGC-803 and RKO cell lines，and induces apoptosis via arresting cell cycle at G2/M phase. Tubulin inhibitor 35 exhibis potent efficacy in gastrointestinal tumor inhibiton (inhibits MGC-803 (IC50=0.09 μM) and RKO (IC50=0.2 μM) cell lines).

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Cell Cycle/DNA Damage

Topoisomerase

Topoisomerase | Microtubule Associated | Apoptosis

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2247047-77-2

331.41

C21H21N3O

>98% (HPLC)

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O=C1C=2C=CC=CC2N(CCC)C3C=4NC=5C=CC=CC5C4CCN13

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(-20℃)

With Ice Pack

≥ 2 years